W. Ali. South Texas College of Law.
The results from several preliminary studies showing a modest blood-pressure- lowering effect with vitamin C supplementation in people with mild elevations of blood pressure have been conﬁrmed in two recent double-blind trials purchase 800mg viagra vigour visa. One of the ways vitamin C exerts this antihypertensive effect is by promoting the excretion of lead cheap viagra vigour 800mg fast delivery. Chronic exposure to lead from environmental sources including drinking water is associated with hypertension and increased cardiovascular mortality. Areas with a soft water supply often have an increased lead concentration in drinking water due to the greater acidity of the water, and people living in these areas may be predisposed to hypertension. It should be noted that soft water is also low in calcium and magnesium, two minerals that have been shown to protect against hypertension. Vitamin C is likely to be more effective when used with other antioxidant nutrients. The combination of 500 mg vitamin C, 600 mg alpha-tocopherol, 200 mg zinc sulfate, and 30 mg beta- carotene per day produced mild reductions in systolic blood pressure compared with a placebo both in subjects receiving antihypertensive therapy and in those who had normal blood pressure. A two-year trial of folic acid and B6 therapy to lower homocysteine was associated with a 3. In one study, vitamin B6 supplementation at a single oral daily dosage of 5 mg/kg for four weeks in 20 people with hypertension demonstrated signiﬁcant reductions in blood pressure (systolic pressure dropped from 167 to 153 mm Hg, and diastolic pressure dropped from 108 to 98 mm Hg) as well as in serum norepinephrine levels. More than 60 double-blind studies have demonstrated that ﬁsh oil supplements are effective in lowering blood pressure. The key to getting results with ﬂaxseed oil may require reducing the intake of saturated fat and omega-6 fatty acids. In one study 1 tbsp per day of ﬂaxseed oil along with a reduction in the intake of saturated fat resulted in a drop of up to 9 mm Hg in both the systolic and the diastolic readings. However, in some instances the body may not be able to keep up with increased requirements, and supplementation may prove useful. Arginine supplementation has been shown to be beneﬁcial in a number of cardiovascular diseases, including hypertension. By increasing nitric oxide levels, arginine supplementation improves blood ﬂow, reduces blood clot formation, and improves blood ﬂuidity. In hypertension, the degree of improvement offered by arginine supplementation can be quite signiﬁcant in some cases,62,63 but in general a dosage of 4 g three times per day will produce only modest decreases (e. The most thoroughly studied of these peptides is derived from a ﬁsh called bonito (a member of the tuna family). Greater reductions are seen in people with higher initial blood pressure readings. Coenzyme Q10 (CoQ10) Coenzyme Q10, also known as ubiquinone, is an essential component of the mitochondria. Although CoQ10 can be synthesized within the body, deﬁciency states have been reported, especially in those taking statin drugs. CoQ10 deﬁciency has been shown to be present in 39% of patients with hypertension.
Radiographs indicated a diffuse soft tissue opacity in the abdomen suggestive of hepatomegaly and ascites order viagra vigour 800mg overnight delivery. Fluid collected by abdominocentesis was characterized as a transudate (low cellularity discount viagra vigour 800mg with mastercard, SpGr=1. Circulatory Disorders Portal hypertension can occur as the result of right atrioventricular valvular insufficiency. In the acute stage, the liver is swollen; as the disease progresses, the organ may be fibrotic and have a shrunken ap- pearance. When liver enlargement is caused by con- gestion, a liver biopsy may result in fatal hemor- rhage. The use of an artificial substrate (eg, Gelfoam) at the biopsy site to facilitate clotting may help con- trol bleeding. Anemic infarctions of the liver, especially of the cau- dal margins, can be seen as a result of bacterial endocarditis. Streptococci or staphylococci are often involved, but other bacteria like Erysipelothrix rhu- siopathiae (formerly E. Radiographs indicated a diffuse soft tissue opacity throughout the abdomen (arrows). The reticu- lolysis that is associated with some liver diseases The following substances are hepatotoxic: arsenic, makes the liver more sensitive to traumatic insult. Birds can also and mycotoxins (especially aflatoxin from Aspergil- survive liver hemorrhage confined to one of the he- lus flavus, A. Degeneration and necrosis of cases and the documentation of blood clots in these hepatocytes are typical with aflatoxicosis. Radiographically, liver enlargement is indis- tinguishable from perihepatic hematoma (Color Fatty degeneration and the feeding of feeds contami- 20. A diagnosis is usually made during endoscopy nated with mycotoxins causing aflatoxin hepatosis or exploratory laparotomy. Ultrasonography is a use- are likely to be involved in the high incidence of liver ful diagnostic tool in these cases. Peanuts and Brazil nuts are notori- ous sources of aflatoxins, but many other seed mix- tures can be contaminated. Neoplasia Treatment Liver tumors can be classed as primary and mul- of Liver Disorders ticentric (metastatic) (see Chapter 25). Examples of the former are hepatoma, hepatocellular carcinoma, cholangioma, cholangiocarcinoma, lipoma, fibroma, fibrosarcoma, hemangioma, and hemangiosarcoma. Generalities about treating avian liver disease can be Examples of metastatic tumors are leukosis/lym- extracted from known etiologies. The single most phosarcoma, rhabdomyosarcoma, renal carcinoma, important treatment seems to be the administration and pancreatic carcinoma (Color 20. Moldy foods and seed-based diets, particularly those con- It has been suggested that there is an association taining peanuts (unless certified mycotoxin-free), between cholangiocarcinoma and the presence of should be avoided. Likewise, it has been suggested that hemo- sisted feeding are indicated in many cases of hepati- chromatosis in mynah birds and aflatoxicosis in tis.
Intrave- nous injection may result in superficial thrombophlebitis generic viagra vigour 800 mg otc, deep vein thrombo- sis order viagra vigour 800mg otc, and pulmonary embolus and chronic complications of limb swelling and venous ulcers. If injection occurs accidentally into an artery, vascular spasm may occur and result in ischemia, which, if prolonged, can lead to gangrene and amputation. Cellulitis and abscesses may be seen around injection sites, and deep abscesses may extend into joints, producing septic arthritis. Skin manifestations of drug addiction may be seen more commonly in opiate rather than stimulant users, even though stimulant users inject more frequently (14). This is partly because stimulants do not cause histamine release and, therefore, are seldom associated with pruritus and excoriations and also because cutaneous complications are frequently caused by the adulter- ants injected along with the opiates, rather than the drugs themselves. Fresh puncture sites, tattoos used to cover needle tracks, keloid formation, track marks from chronic inflammation, ulcerated areas and skin popping resulting in atro- phic scars, hyperpigmentation at sites of healed abscess, puffy hands (lymphe- dema with obliteration of anatomic landmarks and pitting edema absent), and histamine-related urticaria (opiates act on mast cells resulting in histamine release) may be seen. Opiate Intoxication and Withdrawal The characteristics of the medical syndromes in opiate intoxication, over- dose, and withdrawal are given in Table 4. Opiates, such as heroin, may be taken orally, more usually injected, or smoked—chasing the dragon. Chronic administration of opiate drugs results in tolerance (Table 5) to effects such as euphoria mediated by the opiate receptors and to the effects on the autonomic nervous system mediated by the noradrenergic pathways. Tolerance to heroin can develop within 2 weeks of commencing daily heroin use, occurs more slowly with methadone, and may go as quickly as it devel- ops. With abrupt withdrawal of opiates, there is a “noradrenergic storm,” which is responsible for many of the opiate withdrawal symptoms (Table 6). Cyclizine may be taken intravenously in large doses with opiates, because it is reported to enhance or prolong opioid effects, also resulting in intense stimulation, hallucinations, and seizures; tolerance and dependence on cyclizine may also result (17). Many opiate users are also dependent on ben- zodiazepines, and concurrent benzodiazepine withdrawal may increase the severity of opiate withdrawal (18). Substance Misuse 291 Table 4 Medical Syndromes in Heroin Users Syndrome (onset and duration) Characteristics Opiate intoxication Conscious, sedated “nodding”; mood normal to euphoric; pinpoint pupils Acute overdose Unconscious; pinpoint pupils; slow shallow respirations Opiate withdrawal • Anticipatory 3–4 h after Fear of withdrawal, anxiety, drug-craving, drug-seeking the last fix (as acute behavior effects of heroin subside) • Early 8-10 h after Anxiety, restlessness, yawning, nausea, sweating, nasal last fix stuffiness, rhinorrhea, lacrimation, dilated pupils, stomach cramps, increased bowel sounds, drug-seeking behavior • Fully developed 1-3 d Severe anxiety, tremor, restlessness, pilo-erection (cold- after last fix turkey), vomiting, diarrhea, muscle spasms (kicking the habit), muscle pain, increased blood pressure, tachycar- dia, fever, chills, impulse-driven drug-seeking behavior • Protracted abstinence Hypotension, bradycardia, insomnia, loss of energy and appetite, stimulus-driven opiate cravings From ref. Treatment of Opiate Withdrawal Symptomatic treatment of the opiate withdrawal syndrome can often be achieved using a combination of drugs, such as benzodiazepines for anxiety and insomnia; loperamide or diphenoxylate and atropine for diarrhea; promet- hazine, which has antiemetic and sedative properties; and paracetamol or non- steroidal antiinflammatories for generalized aches. Substitution treatment may be required in more severe cases of opiate dependence using a choice of methadone, buprenorphine, or dihydrocodeine. Because street heroin varies in purity, the starting dose cannot be accurately estimated on the basis of the amount of street drug used. Therefore, substitu- tion therapy should be titrated against the symptoms and signs of withdrawal. For example, dihydrocodeine may be commenced in a dose of 120 mg three times a day, with the dose being increased if the patient has demonstrable clinical signs of opiate withdrawal (19). Clonidine and lofexidine act as presynaptic α2-adrenergic agonists, which inhibit the noradrenergic storm associated with opiate withdrawal.